glutcose 6 phosphate dehydrogenase glutathione reductase Pharmacological targeting of glucose-6-phosphate in human erythrocytes by Bay 11–7082, parthenolide and dimethyl fumarate In RBCs, NADPH are produced
In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Correcting glucose 6 phosphate dehydrogenase deficiency with a small molecule activator Nature Communications Glutathione reductase Wikipedia Glucose 6 phosphate dehydrogenase deficiency pathophysiology wikidoc
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