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Inhibiting system Xc lowers intracellular cystine and depletes GSH in transporter-dependent tissues, placing normal cells under sustained oxidative pressure (89)

ROS accumulation with a decrease in GSH due to MEL has been exclusively reported in the in vitro response in human cells, mostly in cancer cells in which MEL exhibits pro-oxidant properties ( GSH1 and GPX1 genes, which encode -glutamylcysteine synthetase and glutathione peroxidase, respectively, in the early exponential phase