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prophylactic agent refers to cancer chemotherapeutics, radiation therapy, hormonal therapy, biological therapy (e.g., immunotherapy), and/or EphA2 or EphA4 antibodies of the invention

NICD then translocates to the nucleus, where it converts the C-promoter binding factor-1 (CBF-1) complex from a transcriptional repressor to an activator, promoting the expression of Notch target genes

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