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70 BCKDK inhibitors are also effective in attenuating insulin resistance in mouse models of obesity, and the development of a new generation of more powerful BCKDK inhibitors is important for diseases that require inhibition of BCAA catabolism

*Correspondence: Wei Zhou, [email protected] This article was submitted to Genetic Disorders, a section of the journal Frontiers in Genetics Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Fontella FU, Pulrolnik V, Gassen E, Wannmacher CM, Klein AB, Wajner M, Dutra-Filho CS (2000) Propionic and L-methylmalonic acids induce oxidative stress in brain of young rats