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If withdrawal symptoms arise, it may be necessary to pause the taper for a period of time or raise the dose of the opioid analgesic to the previous dose, and then proceed with a slower taper

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When bovine endometrial epithelial cells were treated with berberine at 5, 10, or 20 M, Nrf2 signaling was activated, Bax/Bcl-2, Beclin-1, and LC3II increased, whereas p62 decreased